Health Autism Chapter1 Causes, Entiology, Biomedical Abnormalities - GOOD
Health, Autistic Spectrum Disorder Chapter 2 Causes, Entiology, Biomedical Abnormalities GOOD
Is Aron:
ADHD
He fits the description in the Chapter 1 link above.
'Children with this disorder have trouble paying attention, focusing, making good eye contact and remembering what has been said to them. They are easily distracted. If also hyperactive they may be fidgety, in constant motion, moody, quick to anger or to cry and some may be aggressive at times.'
'Many children with ADHD have a SNP (Single Nucleotide Polymorphism: a variance in the gene that codes a protein) for an important brain enzyme called methionine synthase (associated with the D4 receptor for dopamine). The function of this enzyme is to add methyl groups to certain fatty chemicals called phospholipids that reside in the cell membrane. The term “methyl group” refers to a carbon with three hydrogen atoms attached to it.'
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if so he may be Undermethylating?
Methylation
It says here
LewisAllen.ppt Very good article.
Undermethylation: Whole blood hystamine > 70 mcg/dl
Overmethylation: whole blood hystamine < 40 mcg/dl
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And here
walsh.htm
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Most ASD individuals exhibit a genetic tendency for undermethylation. A relative few exhibit a genetic tendency for overmethylation. However, it's important to consider the impact of (1) inadequate diet and (2) inefficient digestion/absorption which is present in most of these individuals. Regardless of innate tendency for methylation, many ASD individuals are starved for all components of the SAM cycle and MTHF. In other words, they are deficient (across the board) in most nutrients. Two of the greatest deficiencies in ASD appear to be B-12 and methionine. B-12 is one of the most difficult vitamins to assimilate in healthy persons, and the situation is much worse if significant G.I. tract problems exist. The principal source of methyl groups is methionine from dietary protein. However, most ASD children receive inadequate amounts of dietary protein AND are very inefficient in cleaving the complex proteins into the amino acid units to enable absorption. Folic acid is also in a deficiency state in many ASD children...... including children with a genetic tendency for overmethylation and folic acid overload.'
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1611.pdf Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
Under methylating: Undermethylation is accompanied by high histamine levels.
'One thing that is absolutely certain is that methionine and/or SAMe usually harm low-histamine (overmethylated persons)..... but are wonderful for high-histamine (undermethylated) persons. The reverse in true for histadelic (undermethylated) persons, who thrive on methionine, SAMe, Ca and Mg..... but get much worse if they take folates & B-12 which can increase methyl trapping.'
'I guess the bottom line is that undermethylated persons generally exhibit very elevated folate levels.... and these persons get worse if additional folate is given.'
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walshMP.htm Over methylating: Aron does not fit the description of symptoms
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Conditions that Dr Walsh feels are associated with over-methylation include: anxiety/panic disorders, anxious-depression, hyperactivity, learning disabilities, low motivation, "space cadet" syndrome, paranoid schizophrenia and hallucinations.'
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COMT
COMT(Catechol O-Methyl Transferase):
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Low COMT = under methylayting = High dopermine. An interesting way to assess dopamine levels clinically is to count the number of blinks per minute. The average number of blinks is 15-30 per minute. The blink rate has been found to vary with the amount of dopamine present: the more dopamine, the more the blinking rate and vice versa.
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Aron blinks once or twice every few seconds. I would say he blinks a lot.
Undermethylation = High Dopermine too
MTHFR
MTHFR Gene
It seems the way to assess methylation activity is to have a MTHFR (methylene- tetrahydrofolate reductase) test. It checks for mutations / variations in the MTHFR Gene.
Here are some links:
Boris.pdf All about it.
MTHFR DNA Test
Molecular test for MTHFR 667C -> T
nutrigenetics.html Help yourself
Histamine and Dopermine
How to tell if he is high or low Dopemine (apart from blink rate) ?
Dopermine is often high in Autistics. See link below.
Histamine and Dopamine
LewisAllen.ppt A
lot in here including Dopamine and Histamine
And it says:
Undermethylation: Whole blood histamine > 70 mcg/dl
Overmethylation: whole blood histamine < 40 mcg/dl
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